急性脑梗死患者血清肿瘤坏死因子-α、白细胞介素-8和瘦素动态测定的临床意义

Clinical Significance of Serum TNF-α、IL-8 and Leptin in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)和瘦素水平的动态变化,并分析它们与脑梗死病情严重性之间的关系。方法:60例急性脑梗死患者,在发病后24 h内入院。分别在入院后d 1、d 3、d 7抽取空腹静脉血3 mL,采用放射免疫测定方法动态检测血清肿瘤坏死因子-α、白细胞介素-8及瘦素的水平,采用欧洲卒中神经功能缺损评分量表(ESS)评价脑梗死的严重程度。同时检测30例健康成人作对照组。结果:脑梗死组肿瘤坏死因子-α、白细胞介素-8和瘦素水平在发病后d 1、d 3、d 7均显著高于对照组(P<0.05),ESS评分与IL-8水平间有明显相关关系(P<0.05)。结论:白细胞介素-8参与了急性脑梗死的发生发展。肿瘤坏死因子-α和瘦素水平增高是急性脑梗死的危险标志。

Objective： To explore the dynamic change of serum tumor necrosis factor - alpha （TNF-α）, interleukin- 8 （IL- 8） and leptin in the occurrence of cerebral infarction and analyze the relationship between IL- 8 and the severity of cerebral infarction. Methods： 60 patients with acute cerebral infarction were admitted to hospital within 24 hours after stroke. The serum levels of TNF-α, IL - 8 and leptin in these patients were measured by radioimmunoassay, and the nervous functions were evaluated by European Stroke Scale （ESS） on days 1,3 and 7 respectively after hospitalization. At the same time, 30 normal adults were set as control group. Results： The levels of serum TNF-α, IL - 8 and leptin in 60 patients with acute cerebral infarction were all higher than those in the controls. There was relationship between ESS and the levels of IL- 8. Conclusion： IL -8 is involved in the occurrence and development of the disease. High serum TNF-α and leptin are risky signs of acute infartion.