氯氮平与阿立哌唑对精神病患者糖代谢的影响研究

Effects of clozapine and aripiprazole on glycometabolism of patients with psychoses

目的探讨氯氮平与阿立哌唑对精神疾病患者糖代谢的影响。方法对128例服用氯氮平、70例服用阿立哌唑治疗的精神病患者在治疗前、治疗第4、8、12w末及终末期测量空腹血糖或餐后2h血糖,比较两组患者糖代谢异常及糖尿病发生率。结果氯氮平导致糖代谢异常或糖尿病较阿立哌唑出现时间早,发生率高,危害性大,两组差异有极显著性(P<0.01);患者病程越长、药物剂量越大、治疗时间越长,糖代谢异常及糖尿病发生率越高。结论抗精神病药物与糖代谢异常及糖尿病关系十分密切,在临床治疗中要定期检查血糖,提高患者治疗质量,促进社会功能全面恢复。

Objective To explore effects of clozapine and aripiprazole on glycometabolism of patients with psychoses. Methods Fasting and 2hour after meal blood glucoses were measured before treatment and at the ends of 4th, 8th and 12th week of treatment in 128 patients with psychoses who took clozapine and 70 ones did aripiprazole, comparisons of glycometabolism abnormality and incidence of diabetes were conducted between the 2 groups. Results Compared with aripiprazole, clozapine produced glycometabolism abnormality and incidence more quickly and had higher incidence and greater harm, difference was the most significant（P〈0.01）. The longer course, larger dosage and longer treatment, the higher incidence of glycometabolism abnormality and diabetes. Conclusion Antipsychotics have close relationship to glycometabolism abnormality and diabetes, so blood glucose should be periodically measured to improve the quality of treatment and promote whole recovery of social function.