首发精神分裂症患者糖耐量异常临床观察

Clinical observations of glucose tolerance for first-episode schizophrenics

目的探讨首发精神分裂症患者糖耐量异常发生的频率。方法对168名首发分裂症患者和100名常人的FBS、NS、C肽等进行测定,并计算胰岛素抵抗指数,比较两组间差异。对其中24名首发精神分裂症合并糖耐量异常者进行严格的饮食管理和健康教育。结果首发精神分裂症患者组糖耐量异常频率明显高于健康对照组;通过饮食管理和健康教育,24名共病患者血糖均明显下降。结论精神分裂症与糖耐量异常有明显相关性,综合干预可有效控制血糖。

Objective To explore the frequency of glucose tolerance for first-episode schizophrenics. Methods The FBS,NS and C peptide were measured and compared in 168 first-episode schizophrenics and 100 normal persons and insulin resistance index was counted. Strict diet management and healthy education were conducted in 24 flrst-episode schizophrenics with abnormality of glucose tolerance. Results Frequency of glucose tolerance was significantly higher in the patients＇ than in the control group; after diet management and healthy education, blood glucose of 24 comorbid patients obviously decreased. Conclusion Schizophrenia is notably related to the abnormality of glucose tolerance, comprehensive intervention could effectively control blood glucose.