3-N-丙酰基-2-芳基-5-(2-氯苯基)-1,3,4-噁唑啉类化合物的合成

Synthesis of 3-N-Propanoyl-2-Aryl-5-(2-Chlorophenyl)-1,3,4-Oxadiazolines

2-氯苯甲酰肼(2)与芳醛反应得到相应的酰腙(3a^3h),而后与丙酸酐脱水环化成了3-N-丙酰基-2-芳基-5-(2-氯苯基)-1,3,4-唑啉类化合物(4a^4h),通过元素分析,IR,1H NMR和MS对化合物4a^4h的结构进行了表征.

4-Chlorobenzoyl hydrazine （2） reaction with arylaldehydes produced corresponding hydrazones （3a - 3h）. Then 3a - 3h respectively cyclodehydrated with propanoic anhydride to afford 3-N-propanoyl-2-aryl-5-（2-chlorophenyl）- 1,3,4-oxadiazolines（4a - 4h）. The structures of 4a - 4h were confirmed by elementary analyses, IR, ^1H NMR and MS spectroscopy.