液闪法研究^(14)C-尿素在小鼠体内的吸收及分布和排泄

Absorption distribution and elimination of ^(14)C-urea in mice

本文报道应用液体闪烁测量方法研究14C-尿素在小鼠体内的吸收、分布和排泄。小鼠口服14C-尿素后,血药浓度时间曲线符合二房室开放模型。吸收速率常数Ka为3.64/h,分布相半衰期T1/2(α)为0.72h,消除相半衰期T1/2(β)为5.15h,清除速率常数CL为0.617L-1.Kg-1.h-1,表观分布容积Vd为5.59L/Kg,达峰时间Tmax为0.11h,峰浓度Cmax为1.57KBq/mL。在所测12种组织中均有14C-尿素存在,0.25h肾中放射性最高,心,肝,脾,肺,肠,胃较多,2h肺中放射性最高,脂肪最少。24h肝中放射性最高。24h粪尿排出给药量的65%,其中46%经尿排出,19%经粪排出。

This paper discussed the applications of instrumental alalysis techniques inthe researching structure, functional group, molecular weight and molecular weightdistribution of lignin. The ultraviolet spectrum was used in identifyingquantifieationally the lignin;The infrared spectrum was used to identity thefunctional group of lignin and its mmfiication. Using the NMR to determine generatedproducts of lignin. And CPC was applied in the detremination of molecular weight andmolecular weight distribution of lignin.