小儿咳喘灵泡腾片治疗小儿咳嗽风热犯肺证(急性支气管炎)临床研究

Clinical Study on Kechuanling Effervescent Troche in Treating Cough in Children for Attacking on the Lung by Wind and Heat (Acute Bronchitis)

目的验证小儿咳喘灵泡腾片治疗小儿咳嗽风热犯肺证(急性支气管炎)的有效性与安全性。方法采用随机分组、双盲双模拟、平行对照的方法进行临床对照研究。结果试验组愈显率为85.71%,中医证候愈显率为71.43%,两组比较差异无显著性意义(P>0.05);对咳嗽、发热等症状的改善情况,两组比较差异无显著性意义(P>0.05);对周围血白细胞计数异常及胸部X线检查改善情况,两组比较差异均无显著性意义(P>0.05)。试验组安全性指标观测未发现与试验药物有关的异常改变。结论小儿咳喘灵泡腾片对小儿咳嗽风热犯肺证(急性支气管炎)治疗效果与对照药小儿咳喘灵口服液无明显差异,且临床用药较安全。

Objective To verify the effectiveness and reliability of Kechuanling Effervescent Troche in treating cough in children for attacking on the lung by wind and heat （acute bronchitis）. Method 46 patients were randomly divided into two groups. Compared by parallel control. Results The effective rate was 85.71% in the treated group, and 71.43% in the manifestations of TCM. There was no obvious difference between two groups （P〉0.05）. There were no obvious difference in lightening cough, fever, and other symptoms （P〉0.05）, and in treating abnormity of WBC and chest X-ray （P〉0.05）. The observation about reliability markers indicated： there were no toxic and side effects. Conclusion There was no obvious difference in the effectiveness on treating cough in children for attacking on the lung by wind and heat （acute bronchitis） between the treated group and the control group. During the reliability observation, Kechuanling Effervescent Troche indicated good clinical reliability.