摘要
目的观察参附注射液对大鼠骨骼肌缺血再灌注损伤的影响。方法采用大鼠骨骼肌缺血再灌注损伤模型,观察参附注射液对大鼠再灌注损伤血浆乳酸脱氢酶(LDH)、肌酸激酶(CK)、丙二醛(MDA)和骨骼肌组织髓过氧化物酶(MPO)、MDA和湿重/干重值(W/D)的影响,并观察骨骼肌超微结构的变化。结果参附注射液能明显降低大鼠骨骼肌缺血再灌注损伤所引起的血浆LDH、MDA、CK和骨骼肌组织MPO、MDA、W/D水平的升高,减轻其组织超微结构的损伤。结论参附注射液对骨骼肌缺血再灌注损伤具有保护作用。
Objective To observe the effect of shenfu injection on ischemia/reperfusion injury in skeletal muscle of rats. Methods To make a model of ischemia/reperfusion injury in skeletal muscle of rats, and observe the plasma level of LDH, CK, MDA and the change of MDA, MPO, W/D in the skeletal muscle, Result Shenfu injection can reduce the heightened plasma level of LDH, CK, MDA and MDA, MPO, W/D of the skeletal muscle, lighten the injury of the ultrastructure. Conclusion Shenfu Injection can protect ischemia/reperfusion injury in skeletal muscle.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第6期30-31,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
甘肃省自然科学基金资助项目(3ZSO41-A25-069)
关键词
骨骼肌
再灌注损伤
参附注射液
skeletal muscle： ischemia/reperfusion injury： Shenfu Injection
