糖肾胶囊对四氧嘧啶加嘌呤霉素糖尿病肾病模型大鼠的影响

Effects of Tangshenjiaonang on Alloxan and Achromycin induced Diabetic Nephropathy Rats

目的观察糖肾胶囊对四氧嘧啶加嘌呤霉素诱发糖尿病肾病模型大鼠的血生化、肾功能、血液流变学的影响。方法制备四氧嘧啶加嘌呤霉素诱发糖尿病肾病模型大鼠,随机分为正常对照组、模型对照组、阳性对照组(糖适平)及糖肾胶囊1.5、3.0、6.0g原药材/kg组,观察用药4周后以上各指标变化情况。结果糖肾胶囊显著降低模型动物空腹血糖值,降低血肌酐、尿素氮(P<0.05或P<0.01),改善肌酐清除率(P<0.01),降低24h尿微量白蛋白排泄率(P<0.01),显著改善模型动物的血液流变学,降低纤维蛋白含量,降低血浆粘度(P<0.01)。结论糖肾胶囊对四氧嘧啶加嘌呤霉素诱发糖尿病肾病模型大鼠有显著防治作用。

Objective To observe the effects of Tangshenjiaonang （TSJN） on biochemistry, renal function and hemorheology of alloxan and achromycin induced diabetic nephropathy rats. Methods The diabetic nephropathy rats induced by alloxan and achromycin were divided into 5 experimental groups, compared with control group, to observe the changes of the indicators shown about. Results TSJN can significantly decrease the level of SCr, BUN, CCr, FIB, plasma viscosity and UAER （P〈0.05 or P〈0.01）. Conclusion TSJN has significant preventive and therapeutic effects on diabetic nephropathy rats induced by alloxan and achromycin.