裙带菜膳食纤维对小鼠肠蠕动及血液流变学的影响

Effects of Alaria pinnatifida Harv. dietary fiber on the intestinal peristalsis and hemorheology in mice

目的:研究裙带菜膳食纤维对小鼠的肠蠕动和血液流变的调节作用。方法:将60只小鼠分为正常对照组、水不溶性裙带菜膳食纤维低剂量组(5%)、高剂量组(10%),连续30d,取30只小鼠进行肠蠕动实验。另外,将30只小鼠统一摘除右眼取血,测定其血液流变学指标中的血细胞比容及全血高切、低切表观粘度。结果:裙带菜膳食纤维高剂量组小鼠的炭末推进百分率与正常对照组相比有明显的差异(P<0.01);裙带菜膳食纤维高剂量小鼠的血细胞比容、全血高切、低切表观粘度及红细胞聚集指数均明显低于对照组(P<0.01或P<0.05)。结论:裙带菜膳食纤维增强小鼠的肠蠕动并且可以降低血细胞比容及全血高切、低切表观粘度,可提高血液的流动性。

Objective：To study the regulative effects of Alaria pinnatifida Harv,dietary fiber on the intestinal peristalsis and hemorheology in mice,and to provide an expermental evidence for the application of Alaria pinnatifida Harv,dietary fiber.Methods：Sixty normal mice were divided into normal group,Alaria pinnatifida Harv,dictary fiber group at low dose（5%）and at high dose（10%）.The intestinal peristalsis in thirteen normal mice was mensured 30 days after insoluble Alaria pinnatifida Harv.dietary fiber had been given.Blood sample was taken from the right eye of another 30 mice to determine their hemorheological indexes such as hematoerit level and apparent viscocity of whole blood high and low shears.Results;In intestinal peristalsis test the carbon powder push pereentage of Alaria pinnatifida Hary.dietary fiber group at high dose had significant difference（P〈0.01）compared with normal control,while the hematocrit level and apparent viscosity of whole blood high and low shears were significantly lower than that of the eontrol（P〈0.01 or P〈0.05）.Conclusion：Alaria pinnatifida Harv.dietary fiber can enhance intestinal peristalsis,reduce hematocrit level and the aqqarent viscosity of whole blood high and low shears,and improve blood fluxion of mice.