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^(11)C-蛋氨酸PET-CT在脑胶质瘤中的应用

The application of ^(11)C-MET PET-CT in cerebral glioma
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摘要 PET-CT将PET和CT有机结合,实现了优势互补,可更全面地检出病灶,诊断更准确;11C-蛋氨酸(11C-MET)是一种能被胶质瘤摄取的氨基酸,其在正常脑组织的摄取明显低于脱氧葡萄糖(FDG),可更好地显示胶质瘤。以11C-MET作为示踪剂的PET-CT在对胶质瘤的诊断、鉴别诊断、预后评价及治疗效果评价等方面优于CT、MRI和18F-FDG PET-CT。 PET-CT imaging is the co-registered images of CT and PET in the same machine, it not only includes the advantages of CT, but includes the advantages of PET, it is more accurate in detecting the tumors, 11^C-methionine（11^ C-MET） is an amino-acid which can be inspect by glioma, and it is inspect less than FDG in normal brain tissue, so it can reveal glioma more cleat. PET-CT with 11^C- MET is better than CT,MR/and PET with 18^ F-FDG in diagnosing, prognosing, and detecting curative effect of glioma.
作者 王广丽 张成琪
机构地区 山东大学山东省立医院
出处 《医学影像学杂志》 2006年第5期522-524,共3页 Journal of Medical Imaging
关键词 神经胶质瘤 诊断 鉴别 体层摄影术 发射型计算机 甲硫氨酸 碳放射性同位素 Glioma Diagnosis,differential Tomography, emission-computed Methionine Carbon radioisotope
分类号 R739.41 [医药卫生—肿瘤] R814.42 [医药卫生—影像医学与核医学]
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参考文献16

  • 1Kracht LW,Friese M,Herholz K,etal.Methyl-[11C]-l-methionine uptake as measured by positron emission tomography correlatesto microvessel density in patients with glioma[J].Eur J Nucl Med MolImaging,2003,30:868-873.
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  • 4Even-Sapir E,Parag Y,Lerman H,et al.Detection of recurrence in patients with rectalcancer:PET/CT after abdominoperineal or anterior resection[J].Radiology,2004,232:815-822.
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二级参考文献2

  • 1N. Sato,M. Suzuki,N. Kuwata,K. Kuroda,T. Wada,T. Beppu,K. Sera,T. Sasaki,A. Ogawa. Evaluation of the malignancy of glioma using 11C-methionine positron emission tomography and proliferating cell nuclear antigen staining[J] 1999,Neurosurgical Review(4):210～214
  • 2Masayuki Sasaki,Yasuo Kuwabara,Tsuyoshi Yoshida,Makoto Nakagawa,Toshimitsu Fukumura,Futoshi Mihara,Takato Morioka,Masashi Fukui,Kouji Masuda. A comparative study of thallium-201 SPET, carbon-11 methionine PET and fluorine-18 fluorodeoxyglucose PET for the differentiation of astrocytic tumours[J] 1998,European Journal of Nuclear Medicine(9):1261～1269

共引文献13

医学影像学杂志
2006年 第5期

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