摘要
NO· and ·O2-combine each other to form peroxynitrite (ONOO-) in vivo. Peroxynitrite is very cytotoxic, and it damages many biomolecules. 3-nitrotyrosine and dityrosine are two main products from the reaction of ONOO-and tyrosine. Lots of metallic ions in vivo influence the modification of tyrosine by peroxynitrite. UV-Vis and Fluorescence spectrophotometer were used to study the catalysis and inhibition of metallic ions on the production of 3-nitrotyrosine and dityrosine in vitro. Present results showed that Co?髤, Cu?髤 and Mn?髤 enhance the production of 3-nitrotyrosine, and among them Co?髤 and Mn?髤 have been reported rarely before about it. In addition, Mn?髤 inhibits the production of dityrosine to a certain extent.
NO and O2^- combine each other to form peroxynitrite （ONOO-） in vivo. Peroxynitrite is very cytotoxic, and it damages many biomolecules. 3-nitrotyrosine and dityrosine are two main products from the reaction of ONOO^- and tyrosine. Lots of metallic ions in vivo influence the modification of tyrosine by peroxynitrite. UV-Vis and Fluorescence spectrophotometer were used to study the catalysis and inhibition of metallic ions on the production of 3-nitrotyrosine and dityrosine in vitro. Present results showed that Co（Ⅱ）, Cu（Ⅱ） and Mn（Ⅱ） enhance the production of 3-nitrotyrosine, and among them Co（Ⅱ） and Mn（Ⅱ） have been reported rarely before about it. In addition, Mn（Ⅱ） inhibits the production of dityrosine to a certain extent.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2006年第6期1113-1117,共5页
Chinese Journal of Inorganic Chemistry
基金
北京市科技新星资助项目(No.2003B05)
北京市自然科学基金(No.2052004)
教育部归国人员启动基金资助项目(No.00099)。
