摘要
盐酸关附甲素的一般药理研究王秋娟，吴玉林，张陆勇，后德辉，刘静涵（中国药科大学，南京２１０００９）关附甲素（ｇｕａｎｆｕｂａｓｅＡ，ＧＦＡ）是从关白附中提取的一种新型结构（二萜类生物碱）的抗心律失常药。已有研究表明它对多种实验性心律失常均有效［１，２...
It was found that GFAH (iv 35,5o mg/kg) had no obvious effects on the normalbehaviour,coordination of gait,lowering coordinative motion and spontaneous activity in mice.It also had no coordinative effect on a subthrcshold dose of sodium pentobarbital in mice.GFAH (iv 5,10,15 ma/ag) caused an obvious reduction of heart rate in anacsthetized cats,prol one P-P and Q-T intervals,but had no effect on QRS waves. They only caused the temporarydecrease of tho blood pressure. GFAH (iv 10, 15, 20 ma/kg) had no obvious effect on the rateand amplitude of respiration in anaesthctized rats.
关键词
关附甲素
药理学
: Guan fu base A hydrochloride (GFAH), Coordinativc motion
Reduction ofheart rate, Electroencephalography (EEG) (on page 14)
