摘要
探讨了不同浓度乙醇对萘普生离子导入透过离体大鼠腹部皮肤的影响，乙醇对萘普生被动扩散具有一定的促渗作用，乙醇浓度为３０％到８０％的萘普生饱和溶液，离子导入时的透皮速率均比药物饱和水溶液离子导入的透皮速率有不同程度的增加，其中乙醇浓度为７０％时药物的透皮速率最大，达到１８５±２３．７ｕｇ／ｈ·ｃｍ２，为被动扩散的６．４倍，药物饱和水溶液离子导入透皮速率的３倍。
The effect of ethanol with various concentrations on iontophorcsis of naproxenhas been investigated. Results showed that cthanol influenced the passive flux of drug throughrat abdominal skin. Compared with the iontophoretic flux of saturated aqueous solution ofdrug, 20%-80% ethanol could increase the iontophoretic flux of drug in various degrees. With70% ethanol, the flux of drug reached to the maximum, i. e., 185 23. 7 ug/h.cm2, which is6.4-fold of passiye flux of drug and 3-fold of flux of saturated aqueous solution of drug withiontophoresis.
基金
浙江省自然科学基金
浙江省卫生厅基金
关键词
萘普生
乙醇
离子导入
促透剂
浓度
: Iontophoresis
Naproxen, Ethanol, Percutanouspenetration
