细胞色素P4502D6基因多态性和药物相互作用

Genetic polymorghism of CYP2D6 and drug interactions

细胞色素P4502D6(CYP2D6)是一种重要的P450系氧化代谢酶,参与多种重要药物的代谢。CYP2D6具有基因多态性,对药物的代谢呈现明显的个体差异。而且CYP2D6能被多种药物竞争性抑制和诱导,药物联用时易产生相互作用。本文从CYP2D6的基因多态性与代谢表型、底物竞争作用、代谢酶的诱导和抑制等方面,探讨CYP2D6基因多态性与药物相互作用的关系。

As one of major cytochrome P450s, CYP2D6 is responsible for many important drugs＇ metabolism. The genetic polymorphism of CYP2D6 is the basis of significant individual variability in the metabolism of drugs. Meanwhile, many drugs can influence the activity of CYP2D6 by competitive inhibition or induction, which is easy to eause interaction in eoadministration. So we will investigate the relations of genetic polymorphism of CYP2D6 to drug interactions from such aspects as phenotype, competitive inhibition of substrates, induction or inhibition of CYP2D6.