盐酸戊乙奎醚对沙土鼠前脑缺血再灌注损伤的保护作用

Protective effects of penehyclidine hydrochloride on transient forebrain ischemia reperfusion injury in gerbils

目的:研究盐酸戊乙奎醚(PHC)对沙土鼠前脑缺血再灌注损伤的保护作用。方法:采用沙土鼠双侧颈总动脉阻断模型,观察PHC对沙土鼠前脑缺血再灌注后卒中症状、病理形态的影响,并测定超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:与模型组比较,PHC 0.08、0.24 mg.kg-1组与阿托品组均明显降低动物缺血再灌注6 h卒中指数,同时PHC可使大脑皮质及海马组织中SOD活性明显升高、MDA含量明显降低。PHC可以减轻再灌注3 d后海马神经元锥体细胞损伤程度。结论:PHC对沙土鼠前脑缺血再灌注损伤具有保护作用。

AIM： To study the protective effects of penehyclidine hydrochloride （PHC） on transient forebrain ischemia reperfusion injury in gerbils. METHODS： The model of transient forebrain ischemia reperfusion was established in gerbils by bilateral carotid artery clamping. The effects of PHC on neurological function scores and the morphous of hippocampal pyramidal neuron of gerbils were observed after receiving transient forebrain ischemia reperfusion. SOD activities and contents of MDA in the hippocampus and cortex of gerbils were measured. RESULTS： In the groups of PHC 0.08, 0.24 mg·kg^-1 and atropine, the stroke index was decreased, compared with the ischemia-reperfusion group after the gerbils received transient forebrain ischemia reperfusion for six hours.PHC could reduce the degree of injury in hippocampal pyramidal neuron after ischemia reperfusion for three days. CONCLUSION： PHC has protective effects on transient forebrain ischemia reperfilsion injury in gerbils.