反复呼吸道感染患儿免疫功能变化及核酪注射治疗疗效观察

Changes in immune function of children patients with repeated respiratory infection and effect of treatment with nucleotide and casein injection

目的:探讨反复呼吸道感染(RRI)患儿免疫功能变化及核酪注射液对其的影响。方法:将45例RRI患儿设为RRI组,用核酪注射液治疗,对照组32例为非RRI的急性呼吸道感染患儿,观察疗效及治疗前后血免疫球蛋白、T细胞亚群变化及植物血凝素(PHA)皮试反应强度。结果:RRI患儿IgAI、gG明显低于对照组(P<0.01、P<0.05),治疗后IgA较治疗前升高(P<0.05)。RRI患儿CD4、CD4/CD8、NK细胞明显低于对照组(P<0.05、P<0.01),治疗后CD4、NK细胞较治疗前升高(P<0.05)。RRI患儿PHA红晕直径较对照组小(P<0.05),治疗后较治疗前增加(P<0.05)。结论:RRI患儿细胞免疫、体液免疫功能均下降,核酪注射液具有提高和调节细胞免疫和体液免疫功能的作用。

AIM： To explore the changes in immune function children patients with repeated respiratory infection （RRI）and the influence of nucleotide and casein injection on it. METHODS： 45 patients with RRI were arranged in therapy group and were injected with nucleotide and casein injection. 32 patients with acute respiratory infection were arranged in control group who were not injected with nucleotide and casein injection. The effect of treatment, change of IgA, IgG, IgM, T-lymphocyle subgroups and reaction intensity of PHA were observed. RESULTS： There were very significant decline of IgA and IgG level （ P〈0.01, P〈0.05 ） in RRI children than those in control group. The IgA level in RRI increased obviously after treatment with nucleotide and casein injection （ P〈0.05）. There were very significant decline of CD4, CD4/CD8 and NK cells levels （ P〈0.05, P〈0.01） in RRI children than those in control group. The CD4, NK cells levels in RRI obviously increased after treatment with nucleotide and casein injection （P 〈 0.05）. The roseola diameter of PHA in RRI children declined significantly （ P〈0.05）. There were obviously increase in roseola diameter of PHA after treatment with nucleotide and casein injection （P 〈 0.05 ）. CONCLUSION： Nucleotide and casein injection boosts and improves cell immunity and fluid immunity.