P120ctn在非霍奇金淋巴瘤中的表达及意义

Expression of P120ctn in Non-Hodgkin's Lymphoma and Its Significance

为了探讨连环蛋白P120(P120catenin,P120ctn)在非霍奇金淋巴瘤(NHL)中的表达及意义,采用免疫组织化学染色的方法对比分析了40例NHL和10例反应性增生(RH)淋巴结的外科活检石蜡包埋组织切片中P120ctn的表达情况。结果显示,在反应性增生淋巴结组织中未检测到P120ctn的表达;而在NHL中P120ctn的阳性检出率为55%(22/40),其中低度恶性及中高度恶性NHL组中的阳性检出率分别为16.7%(2/12)、71.4%(20/28),两组之间比较存在显著性差异(P<0.001)。另外,在肿瘤血管内皮细胞上也发现了p120ctn的阳性表达。结论:P120ctn的表达与NHL的恶性程度密切相关,提示P120ctn在淋巴瘤的恶性增殖过程中可能发挥着重要作用,这对淋巴瘤的诊断和治疗可能具有一定的意义。

To evaluate the expression of P120ctn in non-Hodgkin＇s lymphoma （NHL） and to explore its clinical significance, immunohistocbernistry stain method was applied to comparatively investigate the protein expression of P120ctn in paraffin-embedded lymph node tissue slices from 40 cases of NHL and 10 cases of reactive hyperplasia of lymph node. The results showed that P120ctn was not detected in reactive hyperplasia of lymph node, but was detected in 55% （22/40） cases of NHL. P120ctn expression increased with the tumor malignancy of NHL, there was a significant difference between the expression rates of P120ctn in low grade （16. 7%, 2/12 ） and intermediate to high grade malignant （71.4%, 20/28） NHL （P 〈0.001 ）. Moreover, P120ctn was also detected in vascular endothelial cells of NHL. It is concluded that the level of P120ctn expression is closely related to the malignant grade of NHL, it suggests that P120ctn possibly plays an important role in the malignant proliferation of lymphoma with a certain significance in diagnosis and therapy of lymphoma.