氢质子磁共振波谱在急性脑梗死诊断中的价值

Evaluation of ^1H MR spectroscopy in diagnosing acute cerebral infarction

目的探讨氢质子磁共振波谱在急性脑梗死诊断中的价值。方法采用Philips Gyroscan Intera 1.5T磁共振系统,对16例临床诊断为急性脑梗死的患者采用定点分辨选择序列行单体素氢质子磁共振波谱检查,并与常规MRI及扩散加权磁共振成像(DWI)结果进行比较分析。结果16例中,常规磁共振成像病变区表现为长T1、长T2信号者9例,未见明显异常者7例;扩散加权磁共振成像病变区表现为明显的高信号16例;磁共振波谱表现为NAA峰和NAA/Cr比值有不同程度的下降,波谱在1.33 ppm处可见倒置的乳酸(Lac)双峰16例。结论氢质子磁共振波谱检查对急性脑梗死的诊断明显高于常规MRI,可监测脑梗死的进展,对该病的临床治疗有指导意义。

Objective To evaluate the value of ^1H magnetic resonance spectroscopy （^1H MRS） in the diagnosis of acute cerebral infarction. Methods Sixteen patients with acute stroke symptoms were examined by ^1H MRS of single voxel pointresolved selective spectroscopy （PRESS） in a Philips Gyroscan Intera 1.5T MR system, and the results were compared with those by conventional MRI and diffusion-weighted imaging （DWI）. Results Of the 16 patients, 7 patients was normal and 9 patients cerebral infarction presented as long T1 and long T2 signals on MRI. The cerebral lesions presented as obvious high signals on DWI in all patients. ^1H MRS showed that the NAA peak and NAA/Cr ratio decreased with different degrees, and the peak of Lac at 1.33ppm can be seen in all patients. Conclusion ^1H MRS is superior to conventional MR imaging in diagnosing acute cerebral infarction, ^1H MRS can determine the development of cerebral infarction, this technique has guidable meaning in the treatment of acute cerebral infarction.