摘要
目的对比研究99Tcm-HL91显像和18F-FDG显像诊断乳腺癌的临床价值。方法31例乳腺癌患者行99Tcm-HL91和18F-FDG显像,利用计算机感兴趣区(ROI)技术计算T/NT值(病灶计数/对侧计数),定性和半定量法计算诊断灵敏度。结果病灶摄取18F-FDG和99Tcm-HL91的T/NT值为(3.16±0.57)、(2.14±0.36)(P<0.01);浸润性导管癌和浸润性小叶癌摄取18F-FDG T/NT值为(3.14±0.43)、(3.19±0.27)(P>0.05),摄取99Tcm-HL91 T/NT值为(2.16±0.38)、(2.10±0.32)(P>0.05);病灶T/NT值分布18F-FDG为1.56~9.43(中位值3.15),99Tcm-HL91为1.36~6.28(中位值2.95),两者呈正相关(P<0.01);定性法18F-FDG诊断灵敏度为90%,而99Tcm-HL91为84%;半定量以T/NT值2.0为标准,18F-FDG灵敏度为97%,以T/NT值1.5为标准,99Tcm-HL91灵敏度为90%。结论乳腺癌组织对18F-FDG和99Tcm-HL91均有明显的摄取,呈显著正相关;99Tcm-HL91诊断乳腺癌有较高灵敏度,具有一定临床价值。
Objective To study and compare the diagnostic value of ^99Tc^m-4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime （HL91） hypoxia imaging and ^18F-fluorodeoxyglucose （FDG） dual-head coincidence （DHC） imaging in primary breast cancer. Methods Thirty-one patients with primary breast cancer diagnosed by fine needle aspiration were underwent ^99Tc^m-HL91 and ^18 F-FDG tomography fusion imaging. Regions of interest （ROD were drawn on the tumor （T） and contralateral normal breast tissue （NT）, T/NT ratios were measured for all scans. The diagnostic sensitivity was measured by qualitative and semi-quantitative analysis. Results The T/NT ratio of ^18F-FDG and ^99Tc^m-HL91 in breast cancer were （3.16±0. 57）, （2.14±0.36） （P〈0. 01） ; T/NT ratios of ^18F-FDG in IDC （infiltrating ductal carcinoma） and ILC （infiltrating lobular carcinoma） were （3.14±0.43） and （3. 19±0.27） （P〉0. 05）, and of ^99Tc^m-HL91 were （2. 16±0. 38） and （2. 10±0. 32） （P〉0. 05）. In all 31 patients T/NT ratios of ^18F-FDG ranged from 1.56 to 9.43 （median： 3. 15） and of ^99Tc^m-HL91 was 1.36-6.28 （median： 2.95）. A linear correlation was found between them. The sensitivity of ^18F-FDG and ^99Tc^m-HL91 were 90% （28/31）, 84% （26/31） by qualitative analysis. Using 2.0 of T/TN as diagnostic threshold to ^18F- FDG the sensitivity was 97 %, and 1.5 to ^99Tc^m-HL91 the sensitivity was 90 % in the semi-quantitative diagnosis. Conclusion The breast cancer can uptake ^18F-FDG and ^99Tc^m-HL91 obviously, and a strong positive correlation was found between the uptake of them; ^99Tc^m-HL91 imaging possesses higher sensitivity and a certain clinical value in diagnosing breast cancer.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第5期767-769,共3页
Chinese Journal of Medical Imaging Technology
