N-(5-三氟甲基-1,3,4-噻二唑-2-基)-N'-芳酰基脲的合成、晶体结构及生物活性

Synthesis,Crystal Structure and Biological Activity of N-(5-Trifluoromethyl-1,3,4-thiadiazol-2-yl)-N'-aroylureas

通过2-氨基-5-三氟甲基-1,3,4-噻二唑与芳酰基异氰酸酯反应,合成了10种新的芳酰基脲.它们的结构经元素分析、红外光谱、核磁共振氢谱进行了表征.并用X射线单晶衍射法测定了化合物2j的晶体结构,结果表明,该化合物晶体属三斜晶系,空间群为P-1,a=0.54191(15)nm,b=0.7766(2)nm,c=1.7161(5)nm,α=98.668(5)°,β=95.103(5)°,γ=101.070(5)°,V=0.6955(3)nm3,Z=2,Dc=1.653g/cm3,F(000)=352,μ=0.289mm-1.初步的生测试验结果表明一些目标化合物具有良好的植物生长调节活性.

Ten new aroylureas have been synthesized by the reaction of 2-amino-5-trifluoromethyl-1,3,4- thiadiazole with aroyl isocyanates. Their structures were characterized by IR, 1H NMR spectra and elemental analysis, while the crystal structure of 2j was determined by X-ray single-crystal diffraction. The crystal of this compound belongs to triclinic system with space group P-1, and a=0.54191（15） nm, b=0.7766（2） nm, c= 1.7161（5） nm, α=98.668（5）°, β=95.103（5）°, γ= 101.070（5）°, V=0.6955（3） nm^3, Z=2, Dc= 1.653 g/cm^3, F（000）：352,μ =0.289 mm^-1. The preliminary biological activity tests showed that some title compounds have good activity as plant growth regulator.