四种天然槲皮素-3-糖苷的合成

Synthesis of Four Natural Quercetin-3-O-glycosides

以芦丁为原料,经苄基化、酸水解得到关键中间体3',4',7-O-三苄基槲皮素(3),3与相应的1-溴代乙酰糖在四丁基溴化铵催化下在氯仿-0.25mol?L-1K2CO3溶液中缩合成相应的糖苷,脱去保护基得天然槲皮素3-糖苷类化合物1a～1d.其结构经IR,1HNMR,MS及元素分析确证.

Benzylation of rutin followed by hydrolysis afforded 3＇,4＇,7-O-tribenzylquercetin （3）. Compound 3 was condensed with acetylglycosyl bromides in a two-phase system of chloroform-0.25 mol·L^-1 aqueous potassium carbonate using tetrabutyl ammonium bromide as catalyst to yield the protected glycosides 4a 4d. Removal of protecting group led to target products 1a～1d and the structures of such products 1a～1d were confirmed by IR,^1H NMR, MS spectra and elemental analysis.