摘要
目的:评价诱导化疗加三维适形放射治疗(3DCRT)治疗局部晚期非小细胞肺癌(non-small cell lungcancer,NSCLC)的疗效及并发症。方法:经病理细胞学确诊的35例局部晚期NSCLC患者,采用在3DCRT治疗前给予2~4个周期多西他赛75mg/(m^2·d),21d为1个周期的化疗。结果:中位总生存期18个月,1年生存率为71.4%,2年生存率为37.1%。毒副反应患者能耐受。结论:诱导化疗加三维适形放疗治疗晚期NSCLC可延长生存期,但并不增加放射不良反应。
OBJECTIVE: To evaluate the effect and complication of induction chemotherapy combined with three-dimensional conformal radiation therapy (3DCRT) for local advanced non small cell lung cancer (NSCLC). METHODS: Thirty-five patients with locally advanced NSCLC were allotted to study.. Before 3DCRT, the induction chemotherapy was administered with 2--4 cycles of taxotere 75 mg/m^2 on D1 in the 21 day cycle. RESULTS: The overall median survival time was 18 months. The 1-year overall survival rate and the 2-year overall survival rate were 71.4% and 37.1 %, respectively. The treatment was well tolerated. CONCLUSION: The addition of induction chemotherapy to 3DCRT takes a survival advanced for local NSCLC without increasing toxicities.
出处
《中华肿瘤防治杂志》
CAS
2006年第7期526-527,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
癌
非小细胞肺/药物疗法
癌
非小细胞肺/放射疗法
放射疗法
适形
carcinoma, non small cell lung/drug therapy
carcinoma non small cell lung/radiotherapy
radiotherapy, eonformal