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HAG和HA方案治疗老年急性髓细胞白血病的疗效比较

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摘要 目的比较HAG方案(小剂量高三尖杉酯碱、小剂量阿糖胞苷联合粒细胞集落刺激因子)和HA方案(高三尖杉酯碱、阿糖胞苷)治疗老年急性髓细胞白血病(AML)的疗效。方法将65例AML患者随机分成2组(HAG组31例,HA组34例),分别使用以上2种方案进行化疗,比较2组的临床疗效及不良反应。结果HAG组和HA组完全缓解(CR)率分别为18例(58.1%)、11例(32.4%),有效率分别为25例(80.6%)和19例(55.9%),2组差别有统计学意义;2组均出现一定程度骨髓抑制,但HA组比HAG组出现早、持续时间长且较严重。8例HA方案治疗无效患者改HAG方案治疗,CR4例。结论HAG方案治疗老年AML可获得较满意的疗效,HA方案治疗无效时可试用HAG方案治疗;HAG方案毒副反应比HA方案轻。
作者 刘德斌 张奕加 朱雄鹏 许文前 孙力 骆云龙
机构地区 泉州市第一医院血液科
出处 《福建医科大学学报》 2006年第3期274-276,共3页 Journal of Fujian Medical University
关键词 白血病 粒细胞 急性 三尖杉酯碱类 阿糖胞苷
分类号 R733.7 [医药卫生—肿瘤]
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福建医科大学学报
2006年 第3期

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