癫癎患者听觉事件相关电位的改变和影响因素

Auditory Event-Related Potentials in Epilepsy

目的研究癫疒间患者听觉事件相关电位(P300)的变化及其影响因素。方法原发性癫疒间患者66例(癫疒间组),健康人59例(对照组)。肌电图诱发电位仪测定两组P300波群各成分(N1、P2、N2、P3)潜伏期和波幅、反应时。结果癫疒间组P300波群N1波幅降低,P2、N2、P3潜伏期延长(P<0.05);病程、发病年龄进入P3潜伏期的Logistic回归方程(OR值分别为1.129,0.898)。结论癫疒间患者除有较高水平的认知功能异常,还有警觉、选择、注意的障碍;病程长、发病年龄小是癫疒间患者P3潜伏期延长的危险因素。

Objective To survey cognitive function in epileptic patients by auditory event-related potentials（ERP） and look for the determinant factors contributing to Pa00. Methods 66 idiopathetic epileptic patients enrolled and 59 people whose sex, age, education were compatible as the controls. Auditory ERP and contributing factors of P300 were evaluated. Results The latencies of P2, N2, and P3 were significantly longer and the N1 amplitude of P300 was lower in idiopathetio epileptic patients than the controls. Duration and age on onset had entered the regression equation of P300 latency. Conclusion Disturbance of senior cognitive and the arousal and concentrative functions were shown in epileptice patients. Long duration and young age of onset would prolong the P3 latency in epilepsy.