皮质脊髓束的发育和再生

Development and Regeneration of the Corticospinal Tract

皮质脊髓束(corticosp inal tract,CST)是脊髓中最重要的下行运动传导束,它的受损与临床上的中枢性硬瘫密切相关。CST神经元产生于大脑皮质ⅴ层,在发育过程中有轴突生长过剩及消除现象。不同物种之间CST纤维束生长的时间也不同。GAP-43、CNTF、GDNF等因子在CST的发育过程中起重要作用。CST损伤后,周围的微环境存在抑制性因素,导致其再生困难。目前的再生修复研究大多集中于神经或细胞移植、神经生长因子及抗抑制因子抗体的应用。

Corticospinal tract （CST） is the major descending motor tract in spinal cord, injury of this tract is tightly associated with clinical spastic paralysis. Neurons of CST originate from layer V of cerebral cortex. During developmental process, axons exuberate and then eliminate. Developmental schedule of CST axons is different between varied species. Some factors, such as GAP-43, CNTF, GDNF play important roles in developmental process. Regeneration of CST is very difficult when it＇s injured because there are some inhibitory factors in the surrounding microenvironment. At present, most of studies on repair and regeneration of CST focus on transplantation of nerve or cell and application of neurotrophic factors and antibodies.