骨的Langerhans细胞组织细胞增生症8例临床病理分析

Langerhans cell histiocytosis of bone: a clinicopathological study of 8 cases

目的探讨骨的Langerhans细胞组织细胞增生症的临床病理学特征。方法对8例骨的Langer-hans细胞组织细胞增生症的临床资料和组织形态进行分析并采用免疫组织化学方法检测。年龄4～40岁,平均16岁。男5例,女3例。结果Langerhans细胞组织细胞增生症好发于青少年,组织学上由特征性的Langerhans细胞及嗜酸性粒细胞组成,免疫组织化学检测Langerhans细胞表达CD1a及S-100蛋白。结论Langerhans细胞组织细胞增生症是好发于骨的肿瘤性病变,发生在骨的Langerhans细胞组织细胞症要与慢性骨髓炎及恶性淋巴瘤相鉴别,该病治疗主要是手术刮除病灶及放疗,大多数患者预后良好。

Objective To explore clinicopathological features in Langerhans cell histiocytosis of bone. Methods Eight cases of Langerhans cell histiocytosis of bone were studied by histological evaluation with an immunohistochemistry panel. Results Langerhans cell histiocytosis mainly occurred in younger patients. Histologically, contained typical Langerhans cells and eosinophilic granulocyte. And Langerhans cells were immunohistochemistry positive for CD 1 a and S-100 protein. Conclusions Langerhans cell histiocytosis were tumor-like lesions and it should be distinguished with chronic osteomyelitis and malignant lymphoma when occurred in bone. The patients were treated with operation and radiation therapy. Their prognosis were almost good.