70岁以上老年急性脑梗塞患者红细胞免疫功能的初步研究

A preliminary study on RBC immune function in patients aged over 70 years with acute cerebral infarction

目的评估７０岁以上老年急性脑梗塞患者是否存在红细胞免疫功能的异常。方法应用红细胞葡萄球菌蛋白Ａ（ＳＰＡ）花环试验及红细胞免疫调节因子试验，检测了３１例老年急性脑梗塞患者的红细胞免疫功能，包括红细胞Ｃ３ｂ受体花环率（ＲＲＣＦ）、红细胞ＳＰＡ花环率（ＲＲＳＦ）、红细胞混合花环率（ＲＭＲＦ）、裸红细胞（ＲＮＲ）及循环免疫复合物（ＣＩＣ），并与３０例健康老年人进行了对照。结果老年急性脑梗塞患者ＲＲＣＦ降低（５．９ｌ％±０．７６％），ＲＲＳＦ增高（２４．０ｌ％±２．５３％），ＣＩＣ亦增高（０．２１％±０．０４％），与健康老年人比较，差异有非常显著性（均为Ｐ值７＜０．００１）。结论老年急性脑梗塞患者红细胞免疫功能异常，提示脑梗塞发病过程中免疫机制参与了作用。

Objective It is not clear whether the immune function disturbance esists in aged acute cerebral infarction (ACI) patients. In this study the red blood cell (RBC) immune function in ACI patients aged over 70 years was evaluated to see whether it is abnormal or not. Methods The tests of RBC SPA-resette and RBC immune regulatory factor were used to determine RBC immune function including rate of RBC-C3b receptor rosette formation(RRCF) , rate of RBC-SPA rosette formation (RRCF) , rate of mixed RBC rosette formation (RMRF) , rate of nude RBC (RNR) and level of circulating immune complex (CIC) in 3l patients aged over 70 years with acute cerebral infarction as well as in 30 aged subjects without cerebral infarction. Results The results showed that RRCF (5.91%±0.76%) decreased significantly (P<0.001),RRSF (24.0l%±2.53%) and CIC (0.21%±0.04%)increased significantly (P<0.001) in the aged ACI patients as compared with the controls. Conclusions This result suggests that there is disturbance of RBC immune function in the aged ACI patients.