乌拉地尔预防气管插管时心血管反应的观察

Effects of urapidil on cardiovascular responses to tracheal intubation

46例(ASA Ⅰ～Ⅱ)全麻择期手术患者随机分为A(n=23)、B(n=23)两组。麻醉用安定0.2mg/kg、2.5%硫喷妥钠5mg/kg、琥珀胆碱1.5mg/kg快速诱导气管插管。组A在琥珀胆碱后即静注乌拉地尔0.5mg/kg。结果:组A插管后心血管反应较稳定,SBP、DBP、MAP、HR和RPP分别升高6%、12%、15%、24%和28%;组B插管后上述参数分别升高30%、37%、33%、48%和95%。结果表明乌拉地尔能有效地预防气管插管反应。

To observe the effects of urapidil on the cardiovascular responses to tracheal intubation, forty-six patients (ASA Ⅰ - Ⅱ) were randomly divided into group A (n=23) and group B(n=23). Anesthesia was induced with valium 0.2mg/kg, 2.5% thiopental sodium 5mg/kg and tracheal intubation was facilitated with succinylcholine 1.5mg/kg. Urapidil 0.5mg/kg was intravenously given immediately after administration of succinylcholine in group A. After intubation. SP, DP,MAP,HR and RPP increased by 6%,12%, 15%, 24% and 28% in group A and increased by 30%,37%,33%,48% and 95% in group B respectively. Compared correspondingly with those in group B, the values of the parameters mentioned above decreased significantly in 5 minutes after intuhation in group A(P<0.05 or 0.01). The results suggest that urapidil may attenuate effectively the cardiovascular responses during tracheal intubation.