血浆β-内啡肽对慢性疼痛监测价值的研究

Plasma β-endorphin level in patient with chronic pain

选择慢性疼痛病人(n=36)随机分为两组,分别采用神经阻滞治疗和神经阻滞加小针刀治疗。应用放免方法分别于治疗前、后测定血浆β-内啡肽(EP)水平。进行VAS评分,并评定临床疗效。另测定健康人(n=10)血浆β-EP水平作为正常对照。结果表明,血浆β-EP含量不能客观反映慢性疼痛程度和正确评价治疗效果。

To assess the feasiblity of plasma β-endorphin level's serving as a parameter for pain intensity and analgesic effect, 36 adult patients suffering from chronic pain, were randomly allocated to receiving nerve block (group B,n=19) or that combined with small needle scaple maneuver (group BS,n=17) respectively. Before and after treatment,the venous blood samples were taken to determine the plasma β-endorphin (β-EP) concentration by radioimmunoassay,and the values of visual analog scale (VAS) were recorded. The plasma β-EP levels of 10 selected healthy human acted as normal control. As compared with normal control,the β-EP levels changed unsignificantly in patients with chronic pain (P<0.05). The values of VAS decreased remarkaslely in both group after treatment (P>0.05). The plasma β-EP levels weren't correlated with VAS values before and after treatment (r=-0.16 and —0.28, P<0.05). It is indicated that plasma β-EP level may not objectively reflect the intensity of chronic pain and clinical analgesic effect.