摘要
本文采用ＨＰＬＣ法测定人血浆中ＭＭＣ的含量，血样用氯仿－异丙醇溶液提取，以Ｃ_（１８）柱分离，外标法定量检测，在０．１１～１．１μｇ／ｍｌ范围内线性关系良好，并同时对２种样品处理方法进行了比较。本方法平均回收率为９８．８３％（ｎ＝６）。
A simple and sensitive method using high performance liquid chromatography for determination of mitomycin C in plasma has been developed. Analytial column of BIO-RAD ODS- 10was used. The mobile phase was consisted of a mixture of methanol-phosphate buffer (30 :70) . The 365nm UV detector was selected. Within day precision (SD) and recovery were 0. 17and 98. 83%. The method can be used in study of plasma drug concentration and the pharmacokinetics of mitomycin C.
出处
《药物分析杂志》
CAS
CSCD
北大核心
1996年第2期103-105,共3页
Chinese Journal of Pharmaceutical Analysis
