抗胸腺细胞球蛋白治疗再生障碍性贫血25例临床研究

CLINICAL STUDY ON TWENTY-FIVE CASES SUFFERED FROM APLASTIC ANEMIA WITH ANTITHYMOCYTE GLOBULIN

用抗胸腺细胞球蛋白（ＡＴＧ）治疗再生障碍性贫血２５例，总有效率为７２％（８／２５），缓解率为４４％（１１／２５），病死率１６％（４／２５），死亡４例均系重型再障。８０％以上的再障病例治疗前Ｔ４／Ｔ８倒置，治疗后５８％的病例正常或较前提高。治疗后Ｔ４／Ｔ８持续倒置者的骨髓造血功能恢复也不完全。血清病反应轻者疗效明显优于反应重者（Ｐ＜０．０１）。

Responsible effect of antithymocyte globulin (ATG)was evaluated in 25 cases of aplastic anemia. The total effective rate was 72%(18/25), cure and remission rate 44%(11/25) and death rate 16% (4/25). Four dead cases were all diagnosed as severe type (SAA Ⅰ3,SAA Ⅱ 1). The T4/T8 ratios were inverted in 80% pretreated cases and they were corrected and raised after ATG therapy. It was found that the responsible effect to ATG in group of mild serum sickness was apparently better than that of severe ones (P<0.01).