去甲万古霉素治疗粒细胞缺乏并发危重感染32例疗效分析

Norvancomycin Therapy of Serious Infection in 32 Neutropenic Patients

应用去甲万古霉素治疗粒细胞缺乏并发危重感染32例,总有效率32.5%。检出革兰阳性菌13例,占40.6%,提示粒缺时革兰阳性菌感染机会增加,其中耐药性葡萄球菌占较大位置,及时应用去甲万古霉素常有效,尤其对静脉留置导管者更强调早期使用。

Novancomycin was administered in 32 neutropenic patients with serious infection, and the overall response rate was 62.5%.Thirteen of these infections(40.6%)were proven to be caused by gram-positive organisms,the majority of which were methicillin-resistant staphylococcus aureus and epidermidis.Norvancomycin was usually used.The authors believe that early administra- tion of norvancomycin may be of help to neutropenic patients with serious infection,especially for pa- tients retaining infusion.