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减阻剂用于出血性休克复苏的实验研究 被引量：2

Resuscitation with drag-reducing polymer in lethal hemorrhagic shock
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摘要 Drag reducing polymers (DRPs) provide large drag reductions in turbulent flow at nanomolar concentrations of linear macropolymers,as polyethylene glycol, aloe vera polymer. DRPs have been shown to significantly enhance hemodynamics and improve microcirculation, make the red blood cells work harder and increase blood pressure , improve survival in hemorrhagic shock. Drag reducing polymers （DRPs） provide large drag reductions iu turbulent flow at nanomolar concentrations of linear macropolymers,as polyethylene glycol, aloe vera polymer. DRPs have been shown to significantly enhance hemodynamics and improve microcirculation, make the red blood cells work harder and increase blood pressure , improve survival in hemorrhagie shock.
作者 江学成 李德馨
机构地区 解放军第九七医院麻醉科 南京军区总医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2006年第3期161-163,共3页 International Journal of Anesthesiology and Resuscitation
关键词 drag reducing polymer hemorrhagic shock drag reducing polymer hemorrhagic shock
分类号 R605.971 [医药卫生—急诊医学]
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参考文献24

  • 1Mostardi RA, Greene HL, Nokes RF, et al. The effect of drag reducing agents on stenovie flow disturbances in dogs. Biorheology, 1976 , 13(2) :137-141.
  • 2Polimeni PI, Ottenbreit B, Coleman P. Enhancement of aortic bloood flow with a linear anionic macropolymer of extraordinary molecular length. J Mol Cell Cardiol, 1985,17(7) :721-724.
  • 3Faruqui FI.Otten MD.Polimeni PI.Protection against atherogenesis with the polymer drag-reducing agent Separan AP-30 Circulation,1987,75(3);627-635
  • 4McCloskey CA, Kameneva MV, Uryash A,et al. Tissue hypoxia activates JNK in the liver during hemorrhagic shock. Shock, 2004,22(4) :380-386.
  • 5Macias CA, Kameneva MV, Tenhunen JJ,et al. Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe.veto. Shock, 2004 ,22(2) :151-156.
  • 6Kameneva MV, Wu ZJ, Uraysh A,et al. Blood solable drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.Biorheology, 2004,41 ( 1 ) :53-64.
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  • 9Polimeni PI.Ottenbreit BT.Hemodynamic effects of a poly(ethylene oxide)drag-reducing polymer.Polyox WSR N-60K.in the open-chest rat.J Cardiovasc Pharmacol,1989,14(3):374-380
  • 10Coleman PB.Ottenbreit BT.Polimeni PI.Effects of a drag-reducing polyelectrolyte of microscopic linear dimension(Separan AP-273)on rat hemodynamies. Cite Res, 1987,61 (6) :787-796.

同被引文献34

  • 1车惠民,刘厚东,朱素琼,罗登晨,王端荣.高原失血性休克犬再灌流致肺水肿及右心衰机理[J].中华创伤杂志,1995,11(2):117-118. 被引量：14
  • 2Macias CA,Kameneva MV,Tenhunen JJ,et al.Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera[J].SHOCK,2004,22:151-156.
  • 3Kameneva MV,Wu ZJ,Uraysh A,et al.Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments[J].Biorheology,2004,41:53-64.
  • 4Gutierrez G,Fuller SP.Of hemorrhagic shock,spherical cows and Aloe vera[J].Crit Care,2005,9:304-305.
  • 5Porter JM,Ivaury RR.In search of the optimal end point of resuscitation in trauma patients:A review[J].J Trauma,1998,44:908-914.
  • 6Brostow W, Lobland HEH, Reddy T, et al. Lowering mechanical degradation of drag reducers in turbulent flow. J Materials Res, 2007, 22: 56-60.
  • 7Choi HJ, Lim ST, Lai PY, et al. Turbulent drag reduction and degradation of DNA. Phys Rev Let, 2002, 89: 288-302.
  • 8Polimeni PI, Ottenbreit B, Coleman P. Enhancement of aortic blood flow with a linear anionic macropolymer of extraordinary molecular length. J Mol Cell Cardiol, 1985, 17 : 721-724.
  • 9Coleman PB, Ottenbreit BT, Polimeni PI. Effects of" a dragreducing poly-electrolyte of microscopic linear dimension ( Separan AP-273) on rat he-modynamics. Circ Res, 1987, 61. 787-796.
  • 10Neu B, Armstrong JK, Fisher TC, et al. Aggregation of human RBC in binary dextran-PEG polymermixtures. Biorheology, 2001, 38 : 53-68.

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国际麻醉学与复苏杂志
2006年 第3期

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