心舒胶囊治疗病毒性心肌炎频发室性早搏及对ET、MDA、CRP影响的临床观察

Clinical Observation on the Effect of Xinshu Capsule(XC,心舒胶囊)in Treating Frequent Ventricular Extrasystoles Due to Viral Myocarditis and the Influence on ET,MDA and CRP

目的:观察心舒胶囊治疗病毒性心肌炎频发室性早搏的临床疗效及对ET、MDA、CRP的影响。方法:120例随机分为治疗组和对照组各60例。治疗组口服心舒胶囊,每次10g,每日3次;对照组口服辅酶Q10胶囊,每次20mg,每日3次。治疗前后观察心悸、胸闷、气短、乏力等证候改变,并检查心电图、动态心电图、心肌酶学及ET(内皮素)、MDA(丙二醛)、CRP(C反应蛋白)等指标。结果:对心悸、胸闷、气短、乏力等中医证候,两组治疗后均能明显改善,但治疗组的疗效明显优于对照组;两组对病毒性心肌炎频发室性早搏均有疗效,但治疗组的疗效明显优于对照组(P<0.05);治疗组ET、MDA、CRP都明显降低,ET由68.32±14.68改善为38.58±8.78,MDA由9.32±1.73改善为6.48±1.37,CRP由15.81±6.58改善为5.62±2.63。结论:心舒胶囊治疗病毒性心肌炎频发室性早搏疗效显著,并能明显降低ET、MDA、CRP。

Objective：To observe the effect of XC in treating frequent ventricular extrasystoles due to viral myocarditis and influence on ET, MDA and CRP. Method： 120 cases of frequent ventricular extrasystoles due to viral Myocarditis were randomly divided into the treatment group （60 cases） treated with XC 30 g/d t. i. d. ,and the control group （60 cases） treated with co enzyme Q10 capsule 60 mg/d t. i. d. The symptoms of cardio palmus, chest distress, short breath and asthenia and the electrocardiogram, myocardium enzymology and ET,MDA and CRP were observed before and after treatment. Result. The symptoms were improved in both the two groups. And they were improved more significantly in the treatment group. Both the two groups had therapeutic effect in treating frequent ventricular extrasystoles, and the effect in the treatment group was superior to that in the control group （P 〈 0.05）. ET,MDA and CRP were lowered in the treatment group significantly in the treatment group. Conclusion. XC has significant effect in treating frequent ventricular extrasystoles due to viral myocarditis and lowering ET, MDA and CRP.