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术前应用咪唑安定的临床观察

Clinical Observation on The Effect of Midazolam in Preoperative Administration
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摘要 目的:探讨术前应用咪唑安定的合理剂量。方法:ASA I-Ⅱ级椎管内麻醉或神经阻滞麻醉患者30例,随机分为3组。A组:咪唑安定0.05mg/kg;B组咪唑安定0.075mg/kg;C组咪唑安定0.1mg/kg,每组10例,观察各组入室和肌注30min时的镇静程度和呼吸道通畅程度,随访24h遗忘程度。结果:A组所有患者入室评为4分,B、C组入室时已有90%和100%患者有睡意,24h后各组的遗忘率分别是70%、90%和100%。结论:咪唑安定0.05mg/kg是术前用药的合理剂量。 Objective: Look for the best dose of midazolam for preoperative administration. Methods: 30 ASA2-3 patients who received epidural or spinal anesthesia or nerve block were divided equally into three groups and received 0.05mg/kg,0. 075mg/kg;or 0. lmg/kg midazolam respectively. Studied sedation and airway scores of patients in each group when arriving OR and 30min after muscle injection and evaluted amnesia effects 24 hours after operations. Results:All patients in A group were scored 4 when arriving OR,90 % in B and 100 % in C felt drowsy. Amnesia effects appeared in 70% 90% and 100% patients of A,B and C groups respectively. Conclusions: Giving 0.05mg/kg midazolam is a logical dose for preoperative administration.
出处 《内蒙古医学杂志》 2006年第5期400-401,共2页 Inner Mongolia Medical Journal
关键词 咪唑安定 术前用药 剂量 Midazolam Preoperative administration Dose
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参考文献3

  • 1Detriche O, Berre J, Massant J, et al. The Brussels sedation scale:use of a simple clinical sedation scale can avoid excessive sedation in patients undergoing mechanical ventilation in the intensive care unit[J]. Br J Anaesth, 1999,83 : 698.
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  • 3许立新,余文富,薛张纲,蒋豪.咪唑安定作为术前用药的临床观察[J].临床麻醉学杂志,2004,20(2):119-120. 被引量:11

二级参考文献3

  • 1Alexander CM,Teller LE,Gross JB.Slow injection does not prevent midazolam-induced ventilatory depression.Anesth Analg,1992 ,74 :260.
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