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短效静脉麻醉药物用于无痛人工流产术的临床观察 被引量:1

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摘要 目的:比较短效静脉麻醉药瑞芬太尼和丙泊酚分别单独和联合应用于人工流产手术麻醉的镇痛效果及对术中呼吸循环、术后恢复以及患者舒适度等的影响。方法:将75例早孕妇女随机分为3组(n=25),分别按以下麻醉诱导+维持方案用药:丙泊酚2mg.kg-1+0.2mg.kg.min-1(P组);瑞芬太尼(浓度10μg.mL-1)1.5μg.kg-1+0.15μg.kg.min-1(R组);瑞芬太尼1.0μg.kg-1联合丙泊酚1.0mg.kg-1+丙泊酚0.2mg.kg.min-1(P+R组);所有患者必要时追加丙泊酚静脉推注。监测平均动脉压(MAP)、心率(HR)和脉博氧饱和度(SpO2),观察妇科情况,记录苏醒时间、离开手术室时间、不良反应以及视觉模拟疼痛评分(VAS)疼痛评分,分别由患者和手术者作出麻醉满意度评分,计算每位患者所用药品的总折价。结果:除P组术中MAP显著低于术前水平外,各组MAP、HR和SpO2无显著变化;VAS疼痛评分3组差异无显著性;患者满意度评分P组和P+R组明显高于R组,术者满意度评分P+R组显著高于P组和R组;苏醒和离开手术室时间R组<P+R组<P组;术后恶心呕吐R组最多,注射部位疼痛的例数P组最多;注射后咳嗽P组最少;所用药品的总折价R组<P+R组<P组。结论:瑞芬太尼和丙泊酚复合用于人工流产术,效果较好,不良反应较少,信价比也较高。
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2006年第6期719-721,共3页 Chinese Journal of Hospital Pharmacy
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二级参考文献9

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