焦虑症艾森克个性问卷与血浆去甲肾上腺素、总皮质醇及白介素-2测定及相关分析

The measurement of anxious disorder about eysenck personality questionnare and normetanephrine,cortisol and interlenkin-2 in serum and correlative analysis

目的探讨人格特征和神经生化、内分泌和免疫等因素与焦虑症发病的关系,并对艾森克个性问卷(EPQ)和去甲肾上腺素(NE)、总皮质醇及白介素-2(IL-2)的检测结果进行相关分析。方法(1)对象病例组:符合《中国精神疾病分类与诊断标准-3》(CCMD-3)广泛性焦虑障碍(generalizedanxietydisorderGAD)和惊恐障碍(panicdisorderPD)诊断标准60例患者。(2)EPQ评定。(3)血浆NE、血浆总皮质醇、血IL-2测定。(4)对EPQ和血浆NE、血浆总皮质醇、血IL-2测定结果进行相关分析。结果(1)GAD组与PD组神经质与精神病质均显著高于正常对照组(P<0.05,P<0.001),GAD组和PD组N分和P分均高于正常对照组(P<0.001,P<0.05),E分和L分与正常对照组无显著性差异(P>0.05)。(2)GAD组和PD组血清NE均显著高于正常对照组(P<0.001);GAD组IL-2显著低于正常对照组(P<0.05),而PD组显著高于正常对照组(P<0.001)。(3)GAD组和PD组N分与NE、血浆皮质醇、IL-2均成显著性正相关(P<0.05);两组P分均与NE成显著性负相关,与血浆皮质醇均无相关性,GAD组P分与IL-2无相关性(P<0.05);两组E分与NE显著性正相关,与IL-2无相关性,GAD组E分与血浆皮质醇无相关性,而PD组呈显著性正相关(P<0.05)。结论(1)GAD组和PD组存在神经质和精神质倾向。(2)GAD和PD存在神经生化和免疫改变如NE均增高,GAD血浆IL-2降低而PD增高。(3)从相关分析可知,去甲肾上腺素是所选三个生物学检查与焦虑症人格关系相关程度最高指标。

Objective To explore correlation of personality character and normetanephrine,cortisol and intedenkin-2 in serum with anxiety disorder.Methods All patients who met the criteria of CCMD-3 about anxiety disorder were assigned generalized anxiety disorder （GAD）group and panic disorder （PD）group and measured Eysenck personality questionnare （EPQ） and normetanephrine,cortisol and interlenkin-2 in serum and correlative analysis of scales of EPQ with normetanephrine,eortisol and interlenkin-2 in serum.Results The number of neurotic and psyehosis quality in both GAD and PD groups were sigrfifieanfly more than those of normal controls （P〈 0.05,P〈0.001 ）.The scales of N and P in both groups were significantly higher than those of normal controls （P〈0.001, P〈0.05）.The concentration of normetanephrine in both groups was significantly higher than that of normal controls（P〈0.001）. The concentration of interlenkin-2 in GAD was significantly lower than that of normal controls and the concentration of interlenkin-2 in PD was significantly higher（P〈0.05 ,P〈0.001）.The scale of N in both groups was significantly positively correlation with normetanephrine,eortisol and interlenkin-2 （P〈0.05）.The scales of P in both groups were significantly negatively correlation with normetanephrine and were not correlative with eortisol （P〈0.05）.Conclusion GAD and PD had the trend of neurotic and psychosis quality. GAD and PD had the change of neurobioehemistry and neuroendoerine such for the increase of normetanephrine in GAD and PD serum and the decrease of interlenkin-2 in GAD serum and the increase in PD serum. According to correlative analysis, normetanephrine was the most correlative index with anxiety personality in ehoieed three biological cheeks.