心房颤动患者循环中凝血标志物浓度变化

Change of Concentration of Blood Coagulation Markers in Patients with Atrial Fibrillation

目的研究阵发性、持续性及永久性房颤患者循环中凝血标志物的浓度变化及意义。方法阵发性房颤30例,持续性房颤22例,永久性房颤30例及正常对照组30例,分别测定循环中血浆纤维蛋白原、D-二聚体、血小板膜糖蛋白Ⅱb/Ⅲa浓度并进行比较。结果持续性及永久性房颤患者各项指标均高于阵发性房颤组,差别有显著性,阵发性房颤组与正常对照组间差别无显著性,持续性房颤与永久性房颤组间差别无显著性。结论阵发性房颤患者血中凝血指标无明显增加,而持续性与永久性房颤患者血中凝血指标增加,处于血栓前状态,应给予积极抗凝治疗。

Objective To investigate the different consentrations of blood coagulation markers in patients with atrial fibrillation（AF）. Methods 82 patients with atrial fibrillation were divided into 3 groups ： paroxysmal AF 30, persistent AF 22, permanent AF 30 ;30 people were selected as normal controls. The consentrations of plasma fibrinogen, D - Dimer and GP Ⅱb/Ⅲa were measured and compared in four groups. Results These markers were no significant differences between paroxysmal AF group and normal controls, but these markers in persistent AF group and permanent AF group were significant higher than those in paroxysmal AF group, there was no significant difference on the concentrations of markers between persistent AF group and permanent AF group. Conclusion The mark- ers of blood coagulation were no increasement in paroxysmal AF patients, but increasement in the persistent and permanent AF patients. There were prothrombotic state in patients with persistent AF or permanent AF, so these patients should receive treatment of anticoagulation.