儿童哮喘与肺炎支原体感染关系的探讨

Study on Relationship Between the Infection of Mycoplasma and Bronchial Asthma in Children

目的：探讨儿童哮喘与肺炎支原体感染的关系.方法：对2004年1～10月住院的支气管哮喘合并下呼吸道感染患儿40例及无喘息症状的下呼吸道感染患儿50例,检测外周血肺炎支原体抗体MP-IgM,对比两组支原体抗体阳性率.并对比支原体抗体阳性哮喘患儿与支原体抗体阴性哮喘患儿的外周血嗜酸性粒细胞计数.结果：40例哮喘患儿中,有21例血MP-IgM阳性,阳性率为52.5%;而50例对照组患儿中有14例血MP-IgM阳性,阳性率为28.0%.两组比较有显著性差异（P＜0.01）.支原体抗体阳性哮喘患儿的外周血嗜酸性粒细胞计数明显高于支原体阴性哮喘患儿的外周血嗜酸性粒细胞计数.结论：儿童哮喘与肺炎支原体感染密切相关.

Objective ： To determine the relationship between infection of mycoplasma and bronchial asthma in children. Methods： Two groups of lower respiratory infective children with wheezing symptom （the asthma group, n = 40） or none wheezing symptom （the control group, n = 50） were studied. Mycoplasma- IgM in peripheral blood was detected by enzyme -linked immunosorbent assay （ELISA） in each subject, and the positive rats of Mp - IgM were compared between the two groups. The children in asthma group were divided into two groups, one group were determined as Mp - IgM positive, and the other group were determined as Mp - IgM negative. The count of eosinophils in peripheral blood were compared between the two groups. Results： 21cases were determined as Mp - IgM positive in asthma group and 14 ones in the controls, the positive rates of Mp - IgM were 52.5% and 28% respectively. There was significantly difference （ P 〈 0.01 ） when compared. The count of eosinophils in the group of Mp - IgM positive was more than that in the group of Mg - Igm negative. Conclusion： Bronchial asthma in children was significantly correlated with mycoplasma, and MP is the main cause of repeated attack of asthma.