弥漫性甲状腺肿伴甲亢症患者的生存质量及相关心理社会因素

Quality of life and affective psychosocial factors of patients with Graves’disease

目的比较弥漫性甲状腺肿伴甲亢症患者与正常对照组的生存质量,并研究影响甲亢患者生存质量的心理社会因素。方法采用世界卫生组织生存质量测定简表、特质应对方式问卷、领悟社会支持量表、艾森克人格测验、抑郁自评量表、焦虑自评量表对65例甲亢患者和和64例正常对照进行了测评。结果甲亢组生存质量的生理领域评分[(57.03±13.34)分]比对照组[(67.91±14.46)分]低(P<0.05),生存质量的心理领域评分[(59.57±14.00)分]比对照组(64.84±11.85)低(P<0.05),生存质量的社会关系领域和环境领域的分值也均低于对照组,但差异无显著性。甲亢组生存质量的生理领域与家庭外支持呈正相关(γ=0.249,P<0.05),与消极应对呈负相关(γ=-0.310,P<0.05);生存质量的心理领域与消极应对呈负相关(γ=-0.388,P<0.05);生存质量的社会关系领域与家庭内支持呈正相关(γ=0.262,P<0.05),与神经质呈负相关(γ=-0.292,P<0.05);生存质量的环境领域与家庭内支持呈正相关(γ=0.347,P<0.05),与家庭外支持呈正相关(γ=0.276,P<0.05),与积极应对呈正相关(γ=0.262,P<0.05)。结论甲亢患者生理领域和心理领域的生存质量比正常对照差,影响生存质量的心理社会因素主要是应对方式和社会支持。

Objective To investigate the quality of life and relevant psychosocial factors in patients with Graves＇ disease. Methods 65 patients and 64 normal controls were assessed using World Health Organization Quality of Life Questionaire abbreviated version （WHOQOL-BREF）, Trait Coping Style Questionaire, Perceived Social Support Scale,Eysenck Personality Questionaire（EPQ）,Self-Rating Anxiety Scale（SAS） and Self-Rating Depression Scale （SDS）. Results All domain scores of quality of life were lower than that of health controls, but only PHYS （57.03 ± 13.34）and PSYCH （59.57 ± 14.00）domain scores had significantly differences than that of health controls（67. 91 ± 14.46 vs 64.84 ± 11.85 ） （ P 〈 0.05）. In Graves＇ group, PHYS domain scores was positive related with social support outside family （γ = 0.249, P〈 0.05 ）, and negative related with negative coping （γ = - 0. 310, P 〈 0.05 ） ; PHYCH domain score was negative related with negative coping （ γ = - 0. 388, P 〈 0.05 ） ; SOCIL domain score was positive related with family support（ γ = 0. 262, P〈 0.05 ）, and negative related with the score of EPQ-N （ γ = - 0.292, P 〈 0.05 ） ; ENVIR domain score was positive related with social support in （ γ = 0. 347, P 〈 0.05 ） and outside （ γ = 0. 276, P 〈 0.05 ） family, and positive related with positive coping （ γ = 0. 262, P〈 0.05）. Conclusion .The quality of life in PHYS and PSYCH domains of patients with Graves＇ disease were poor,and some psychosocial factors affected the quality of life of patients with Graves＇ disease.