1[1]Thiagarajan DG,Bennink MR,Bourquin LD,et al.Prevention of precancerous colonic lesions in rats by soy flakes,soy flour,genistein,and calcium[J]..Am J Clin Nutr,1998,68:1394-1399.
2[2]Constantinou AI,Krygier AE,Mehta RR.Genistein induces maturation of cultured human bresat cancer cells and prevent tumor growth in nude mice[J].Am J Clin Nutr,1998,68:1426-1430.
3[3]Zhou JR,Mukherjec P,Cugger ET,et al.Inhibition of murine bladder tumorigenesis by soy isoglavones via alterations in the cell cycle apoptosis,and angiogenesis[J].Cancer Res,1998,58:5231.
4[4]Yiwei Li,Sunil Upadhyay,Mahbubur Bhuiyan,et al.Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein[J].Oncogene,1999,18:3166-3172.
5[5]Jean-Marie Darbon,Marie Penary,Nathalie Escalas,et al.Distinct Chk2 Activation Pathways Are Triggered by Genistein and DNA-damaging Agents in Humen Melanoma Cells[J].The Journal of Biological Chemistry,2000,275(20):15363-15369.
6[1]Kelloff GJ, Crowell JA, Hank EJ, et al.Strategy and planning for chemopreventive drug development: Clinical development plans Ⅱ [J]. J CellBiocbemSuppl, 1996, 26:54-71.
8[6]An J, Tzagarakis-Foster C, Scharschmidt TC,et al. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens[J].J Biol Chem, 2001, 276: 17808-17814.
9[7]Hom-Ross PL, Barnes S, Lee M, et al. Assessing phytoestrogen exposure in epidemiologic studies: development of a database [J]. Cancer Causes Control, 2000, 11: 289-298.
10[8]MessinaMJ, Loprinzi CL. Soy for breast cancer survivors: a critical review of the literature [J]. J Nutr, 2001, 131: 3095s-3108s.
8Parkin DM, Bray F, Ferlay J. Global cancer statistic,2002 [ J ]. CA Cancer J Clin,2005,55(2) :74 -108.
9Trock BJ,Hilakivi-Clarke L,Clarke R. Meta-analysis of soy intake and breast cancer risk [ J ]. J Nail Cancer Inst,2006,98 ( 7 ) : 459 -471.
10Mense M,Hei TK, Ganju RK, et al. Phytoestrogens and breast cancer prevention: possible mechanisms of action [ J ]. Environ Health Perspect, 2008,116 ( 4 ) :426 - 433.
