mTOR信号转导通路与心肌纤维化

mTOR Signal Transduction Passageway and Myocardial Fibrosis

哺乳类动物雷帕霉素靶蛋白简称mTOR,是磷脂酰肌醇激酶-相关激酶家族(PIKKs)的一员,除蛋白激酶功能外,还是一种重要的信号转导分子,是控制蛋白质翻译和细胞周期进展的重要调控因子,也是调控PIKKs和蛋白激酶B(PKB/Akt)途径的关键因子,能够活化下游蛋白激酶核糖体生物合成和mRNA翻译过程,对细胞由G1期向S期发育起重要作用,控制多种生物酶的产生和活化,对转录也有重要的调控作用。mTOR促进心肌纤维化作用的机制主要为调控胶原蛋白的合成与稳定,并与TGF-β和αvβ3整合素信号通路相互作用,影响细胞外基质的产生。

The mammalian target of rapamycin （roTOR）,a member of the phosphoinositide 3-kinase-related kinase family, is an important signal transduction molecule besides the function of protein kinase. The functions of roTOR as a central controller of protein tranalafion and cell cycle progression have been well defined, roTOR is also a key factor in regulating the phosphatidylinnsitol 3-kinase （PI3K） and protein kinase B （Akt） pathways, which can activate both ribosomal biosynthesis and mRNAs translation of protein kinases,play an important role in cell development from G1 phase to s phase, control the production and activation of many kinds of enzyme and play a key role of in transcription. The mechanism of roTOR accelerating myocardial fibrosis is to control the synthesis and stability of collagen protein and to affect the information of extracellular matrix as well as the interaction with TGF-βand avβ3 integrin signal pathway.