复方结合雌激素片的动物药效学研究

Study on animal pharmacodynamics of compound conjugated estrogens tablets

目的:评价复方结合雌激素片的主要药效学作用。方法:昆明种雌性未成年小白鼠100只随机分为空白对照组、阳性对照组及结合雌激素低、中、高剂量组,采用小鼠子宫增重试验检测各组结合雌激素的活性;新西兰雌性未成年白兔40只随机分为空白对照组、阳性对照组及醋酸甲羟孕酮低、中、高剂量组,采用兔子宫内膜转化试验检测各组孕激素的活性。结果:雌性未成年小白鼠空白对照组、阳性对照组及结合雌激素低、中、高剂量组的子宫重分别为:(9.272±2.478)(、25.56±5.06)、(15.31±1.10)(、22.47±4.83)(、25.48±5.67)mg/10 g;新西兰雌性未成年白兔空白对照组、阳性对照组及醋酸甲羟孕酮低、中、高剂量组的Mcphail指数分别为:0、3.3±0.3、3.0±1.1、3.1±0.8、3.3±0.5。结论:复方结合雌激素片具有明显的雌激素活性及一定的孕激素活性。

Objective： To evaluate the pharmacodynamics function of compound conjugated estrogen tablets. Methods： Young female mice of Kunming species were randomly divided into the different dosages groups, including control groups, and detecting estrogenic activity by increasing uterus weight; Young female rabbits of New Zealand were randomly divided into the different dosages groups, including control groups, detecting progestational activity by proliferation of rabbit endometrium. Results： The uterus weight of mice of bare control group, positive control group and different dosage groups were increased after taking doses： （9.272±2. 478）, （25. 56±5.06）, （15. 31 ±1. 10）, （22. 47±4. 83）, （25. 48±5. 67） mg/10 g respectively. The mephail index in young female rabbits of different dosages groups were： 0, 3.3±0.3, 3.0±1.1, 3.1±0.8, 3.3±0.5 respectively. Conclusion： The compound conjugated estrogens tablets possess the estrogenic and progestational activities.