摘要
本文介绍了RNAi的发现及作用机理,总结了RNAi抑制A型流感病毒、口蹄疫病毒、登革热病毒和猪瘟病毒复制的机理,并讨论RNAi基础上抗病毒治疗的可能性。虽然RNAi的应用还有一定的局限性,但仍然被认为是对抗病毒感染最有效的方法之一,并具有非常光明的前景。
出处
《广东畜牧兽医科技》
2006年第3期20-23,共4页
Guangdong Journal of Animal and Veterinary Science
参考文献18
-
1Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in C.elegans[J]. Nature, 1998, (391):806-811.
-
2Timnons L, Court D, Fire h. Ingestion of bacterially expressed dsRNhs can produce specific and potent genetic interference in Caenorhabditis elegans[J].Gene, 2001, (263):103-112.
-
3Hamsond SM, Berstein E, Beach D, et al. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells[J].Nature, 2000,(404):293-296.
-
4Verdel A, Jia S, Gerber S, et al. R NAi-mediated targeting of heterochromatin by the RITS complex[J].Science, 2004, 303 (5658) :672-6.
-
5Haasnoot PC, Cupac D, Berkhout B. Inhibition of virus replication by RNA interference[J].J Biomed Sci, 2003,10(6 Pt 1):607-16.
-
6Adelman ZN, Blair CD, Carlson JO, et al. Sindbis virus-induced silencing of dengue viruses in mosquitoes[J].Insect Mol Bio, 2001, (110):265-273.
-
7Ge O, McManus MT, Nguyen T. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription[J]. Proc Natl Acad Sci USA. 2003,100(5):2718-23.
-
8Ge Q, Filip L, Bai A. Inhibition of influenza virus production in virus-infected mice by RNA interference[J].Proc Natl hcad Sci USA. 2004,101(23):8676-81.
-
9Tompkins SM, Lo CY, Tumpey TM, et al. Protection against lethal influenza virus challenge by RNA interference in vivo[J].2004,101(23):8682-6.
-
10Zhou Y, Chan JH, Chan AY, et al. Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian cells[J].FEBS Lett, 2004,577(3):345-50.
-
1马林风.防控仔猪流行性腹泻的建议[J].中国畜牧兽医文摘,2016,32(2):130-130.
-
2魏战勇,黄克和,高晓平.硒与病毒感染[J].畜牧与兽医,2006,38(8):54-57. 被引量:1
-
3侯济堂.一例犬细小病毒病的诊治[J].湖北畜牧兽医,2014,35(2):56-57.
-
4泰国关注禽流感及登革热病毒是否“杂交”[J].中国动物检疫,2006,23(9):24-24.
-
5对付登革热的妙计[J].大科技(科学之谜)(A),2009(7):5-5.
-
6广东出现登革热疫情[J].少年大世界(小学4-6年级),2014(11):57-57.
-
7冯现明,林向武,琤琤靳,侯勇.林州市犬伪狂犬病诊断与流行病学调查[J].农民致富之友,2013(14):219-219.
-
8任武泽,潘洁,孙世铎,庄娟,徐泉兴,饶忠,尤永进.利用RNAi抑制口蹄疫病毒的复制(英文)[J].中国兽医学报,2004,24(5):453-456. 被引量:3
-
9尚丰格,董琼阁.应用丹参注射液治疗犬细小病毒病疗效观察[J].兽医导刊,2015,0(14):59-59.
-
10宋爱军,陈伟,李京玉.登革热的防控[J].畜牧与饲料科学,2010,31(11):157-158. 被引量:1