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连续性血液滤过合用乌司他丁治疗多脏器功能不全综合征

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摘要 目的观察连续性血液滤过(CVVH)和乌司他丁(UT)治疗多脏器功能不全综合征(MODS)的疗效。方法39例MODS患者随机分为组Ⅰ(20例)和组Ⅱ(19例),在常规治疗的基础上,分别予CVVH+UT和CVVH治疗5 d,观察两组的临床表现、病死率I、CU住院天数、APACHEⅡ评分和检测血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的变化。结果两组的临床表现及死亡率无显著差别,但在肾功能恢复和ICU平均住院天数上组Ⅰ显著优于组Ⅱ(P<0.05);CVVH治疗可使APACHEⅡ评分、CRP、IL-6和TNF-α显著下降(P<0.01);停止CVVH后组Ⅱ上述指标显著升高(P<0.05),组Ⅰ上升则不显著。结论CVVH能很好地清除MODS患者的炎症因子,改善临床症状;CVVH结束后出现反复。CVVH结束时加用UT能减轻这种反复,促进肾功能恢复,缩短ICU住院天数。
出处 《中国急救医学》 CAS CSCD 北大核心 2006年第6期458-459,共2页 Chinese Journal of Critical Care Medicine
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参考文献7

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