1McGinnity DF,Soars MG,Urbanowicz RA,et al.Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance[J].Drug Metab Dispos,2004,32(11):1247-1253.
2Sohlenius-Sternbeck AK,Schmidt S.Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes[J].Xeno-biotica,2005,35(7):727-736.
3Gebhardt R,Hengstler JG,Muller D,et al.New hepatocyte in vitro systems for drug metabolism:metabolic capacity and recommendations for application in basic research and drug development,standard operation procedures[J].Drug Metab Rev,2003,35(2/3):145-213.
4Lau YY,Chen YH,Liu TT,et al.Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability[J].Drug Metab Dispos,2004,32(9):937-942.
6Veuthey JL,Souverain S,Rudaz S.Column-switching procedures for the fast analysis of drugs in biologic samples[J].Ther Drug Monit,2004,26(2):161-166.
7Wu JT.The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on-line extraction for high throughout screening of drug candidates in biological fluids[J].Rapid Commun Mass Spectrom,2001,15(2):73-81.
8Fang L,Cournoyer J,Demee M,et al.High-throughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer[J].Rapid Commun Mass Spectrom,2002,16(15):1440-1447.
9Houston JB.Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance[J].Biochem Pharmacol,1994,47(9):1469-1479.
10Jones HM,Houston JB.Substrate depletion approach for determiningin vitro metabolic clearance:time dependencies in hepatocyte and microsomal incubations[J].Drug Metab Dispos,2004,32(9):973-982.
