慢性乙型肝炎中医证型与拉米夫丁应答的关系

The Respondence to Relation between Diagnostication of Traditional Chinese Medicine and Lamivudine in Chronic Hepatitis B

目的:评价慢性乙型肝炎不同的中医辩证分型与拉米夫丁抗病毒效应的关系。方法:选择慢性乙型肝炎84例,按中医辨证分肝胆湿热42例、肝郁脾虚42例。两组均以拉米夫丁100mg,qd,口服观察用药后第1、2、4、,8、12、52周病人血清乙肝两对半定性和HBV-DNA定量。结果:治疗12周后肝胆湿热、肝郁脾虚两组的HBV-DNA累计阴转率分别为90.6%和71.9%,治疗52周后两组的HBeAg阴转率分别为肝胆湿热65.6%、肝郁脾虚40.6%,P<0.05。HBeAg/抗HBe转换率分别为肝胆湿热34.4%、肝郁脾虚15.6%,P<0.05。结论:慢性乙型肝炎不同的中医辩证分型与拉米夫丁抗病毒效应有一定的相关性。

Objective： To assess anti-virus efficiency relation affected by different diagnostication of Traditional Chinese Medicine and lamivudine in chronic hepatitis B.Methods： 84 cases of chronic hepatitis B were divided into two groups according to traditional chinese medicine of syndromes.Damp heat of liver and gall and stagnation of the liver-Qi and deficiency of spleen. Every one of groups took orally 100 mg lamivudine daily for 52 weeks and observed 1,2,4,8,12 and 52 weeks quantity of serum HBsAg HBeAg HBV-DNA, Results： By twelve weeks treatment, 90.6 % and 71.9 % patients of two groups had undetectable serum HBV-DNA,respectively. After 52 weeks undetectable serum HBeAg of two groups was achieved 65.6 % and 40.6,respectively.HBeAg anti-HBe seroconversion was achieved 34.4 % and 15.6 % P〈0.05, Conclusion： There was certain correlation between different diagnostication of Traditional Chinese Medicine and lamivudine in the treatments of chronic hepatitis B.