非淋菌性泌尿生殖道炎支原体感染及耐药变迁

Infection and drugs susceptib ility tests of M ycoplasmain nongonococcal gen itourethritis

目的探讨解脲支原体(Uu)及人型支原体(Mh)在非淋菌性泌尿生殖道炎的感染状况,分析近3年来支原体的感染及耐药变迁。方法采用培养法(Mycop lasm a IST)对NGGU的分泌物进行支原体的培养、体外药敏试验及分析。结果支原体阳性率为47.0%,其中Uu阳性率为34.0%,Uu+Mh阳性率为11.4%,Mh阳性率为1.6%;交沙霉素、强力霉素等药物的敏感率无明显变化,而喹诺酮类的耐药率则呈逐渐上升趋势,环丙沙星及氧氟沙星的耐药率分别从2002年的38.9%及40.0%上升到了2004年的79.2%及66.4%。结论支原体的耐药率正逐步增加,其中喹诺酮类的高耐药率提示其在治疗支原体感染中的地位改变,泌尿生殖道支原体的药物敏感监测对临床治疗具有重要意义。

Objective To study information about infection and drug resistance characteristics in Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh）. Methods Mycoplasma IST kits were used to culture Mycoplasma in nongonococcal genitourethritis patients with secretion and to analyze the drugs susceptibility for three years. Results Among 711 cases,myeoplasma positive rate was 47.0% ,Uu positive rate was 34.0% ,Uu ＋ Mh positive rate was 11.4% ,Mh positive rate was 1.6% ;The result of susceptibility showed that the tendency of drug resistance was growing year by year. The ciprofoxacin and ofloxacin showed a high resistance rate. Josamycin and doxycyclin were sensitive antibiotics. Conclusions The drug resistance of mycoplasma was increasing with time. The ciprofoxacin and ofloxacin was not main drugs for mycoplasma. Drug resistance test could be used to supervise the treatment and to give doctors a guidance.