冠心病患者阿司匹林抵抗与炎症因子相关性研究

Correlation study of aspirin resistance and inflammatory factors in patients with coronary heart disease

目的探讨冠心病患者阿司匹林抵抗(AR)与炎症的关系。方法对110例冠心病心绞痛服用阿司匹林患者及健康对照组采用比浊法测定花生四烯酸(AA)、二磷酸腺苷(ADP)诱导的血小板聚集率,按标准将患者分为阿司匹林抵抗(AR)组、阿司匹林半抵抗(ASR)组和阿司匹林敏感(AS)组;测定血常规,放免法测定白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及超敏C-反应蛋白(hs-CRP)。结果入选患者AR发生率为2.73%;ASR发生率为7.27%,其中ADP诱导者占5.45%,AA诱导者占1.82%;AR或ASR合计为10.00%,而AS发生率为90.00%。对各组hs-CRP、IL-1β及IL-6三种炎症因子研究发现,AR与IL-1β无关;AR组或ASR组患者虽然hs-CRP呈上升趋势,但较AS组差异无统计学意义,而IL-6则较AS组显著上升。结论hs-CRP、IL-1β不适合作为AR的预测和筛查指标,而IL-6的升高与AR密切相关。

Objective To investigate correlation between aspirin resistance（AR） and inflammatory factors. Methods One hundred and ten patients with coronary heart disease took aspirin 0.1 mg/d [or 14 days. It wan detected platelet aggregation function induced with adenosine disphosphate （ADP） and arachidonic acid （AA）, and investigated correlation between AR and inflammatory factors. Interleukin - 1β （ IL - 1β）, interleukin - 6 （ IL- 6） and high sensitive C - reaction protein （ hs - CRP） levels. Results IL- 6 level of patients with AR was significantly higher than that of aspirin sensitive （AS） patients, The other two index were not different between the two groups. Conclusion IL- 6 levels could be used as predictor.