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异基因骨髓间充质干细胞与外周造血干细胞联合移植治疗白血病2例分析 被引量：2

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摘要 目的初步探讨异基因骨髓间充质干细胞(BM-MSC)与外周血造血干细胞(PBSC)联合移植治疗白血病的安全性、疗效,以及对造血重建、移植物抗宿主病(GVHD)及移植物抗白血病(GVL)的影响。方法采用体外培养扩增供者骨髓间充质干细胞(MSC),联合组织相容白细胞抗原(HLA)全相合PBSC共同移植治疗2例白血病。结果联合移植无明显不良反应。中性粒细胞(ANC)≥0.5×109/L的时间分别为移植后15d、17d,血小板(Pt)≥20×109/L的时间分别为移植后21d、25d。移植后30d经短串联重复序列-聚合酶链反应(STR-PCR)显示完全供者型植入。1例发生Ⅱ度急性GVHD(aGVHD)。2例患者移植后均获完全缓解(CR),目前持续CR。结论MSC联合HLA全相合PBSC移植治疗白血病安全、有效、可行性大,MSC对异基因造血干细胞移植(Allo-HSCT)造血重建有促进作用,对GVHD及GVL的影响有待进一步研究。
作者 廖爱军 刘卓刚 杨威 王欢 李迎 张嵘
机构地区 中国医科大学附属第二医院血液科
出处 《中国医师进修杂志（内科版）》 2006年第6期39-40,共2页 Chinese Journal of Postgraduates of Medicine
基金 辽宁省科技厅自然科学基金资助项目(20042078)
关键词 间充质干细胞 造血干细胞 白血病 移植物抗宿主病 移植物抗白血病
分类号 R457.7 [医药卫生—治疗学] R329.2 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献8

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二级参考文献8

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共引文献9

同被引文献38

  • 1孟丽娟,李建勇,陆化,吴汉新,吴冠宇,朱雨,刘澎,黄峻.间充质干细胞体外扩增联合自体外周血造血干细胞移植治疗恶性血液病[J].苏州大学学报（医学版）,2005,25(2):252-255. 被引量：5
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  • 3石亮,王季石.人间充质干细胞免疫调节活性与干细胞移植[J].中华血液学杂志,2006,27(2):141-144. 被引量：3
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中国医师进修杂志（内科版）
2006年 第6期

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